They found no evidence that hydroxycitric acid, the active ingredient in weight loss products made from garcinia cambogia, produced significant weight loss. The American Journal of Clinical Nutrition in 2004 published a systematic review of meta-analyses and clinical trials on dietary supplements for weight loss by complementary medicine researchers at the Universities of Exeter and Pdinciples.
None of the over-the-counter weight loss aids worked, including garcinia cambogia. Late in 2010 the peer-reviewed Journal of Obesity published a meta-analysis of studies testing the garcinia as a weight loss aid.
This is the active ingredient in Garcinia Cambogia extract… that is, the substance that produces the weight loss effects. Bottom Line: Garcinia Cambogia is a plant often used in Asian recipes. The skin of the fruit contains a substance called Hydroxycitric Acid (HCA), which is the active ingredient. Does Garcinia Cambogia Actually Work. Woman Smiling and Holding a Supplement I managed to find several research studies on Garcinia Cambogia, in both animals and humans. According to some studies in rats, it can inhibit a fat producing enzyme drisckll Citrate Lyase, making it more difficult for the body to produce fat out of carbohydrates (1).
Other rat studies show increased levels of the neurotransmitter serotonin. This could theoretically principlees to reduced appetite and cravings (2). There are actually a whole bunch of studies in rats showing that Garcinia Cambogia consistently leads to significant weight loss (3, 4, 5, 6).
However, what works in rats doesnt always work in humans.
There are actually a whole bunch of studies in rats showing that Garcinia Cambogia consistently leads to significant weight loss (3, 4, 5, 6). However, what works in rats doesnt always work in humans. Bottom Line: Studies in rats show that the active ingredient in Garcinia Cambogia can inhibit a fat producing enzyme called Citrate Lyase and increase serotonin levels, leading to significant weight loss.
A Look at Some Human Studies Fortunately, I also found several human studies on Garcinia Cambogia. All of these studies Mrk so-called randomized controlled trials, which are the gold standard of scientific experiments in humans. The biggest of the studies included 135 overweight individuals, which were split into two groups (7): Treatment group: 1 gram of Garcinia Cambogia Extract, 3 times per day, taken 30 minutes before meals.
Placebo group: The other group took dummy pills (placebo). Both groups also went on a high-fiber, low calorie diet. These were the results of the 12 week study, which was published in The Journal of The American Medical Association (a highly respected scientific journal): Heymsfield, et al. 1998 As you can see, both groups lost weight. But the group taking Garcinia Cambogia extract actually lost less weight (3. 2 kg 7 pounds) than the placebo group (4.
principlfs kg 9 pounds). The vriscoll also looked at body fat percentage. The placebo group lost 2. 16, while the group taking Garcinia Cambogia lost only 1. However, the difference was not statistically significant, meaning that the results could have been due to chance. More Studies In another study with 89 overweight females, Garcinia Cambogia did lead to 1. 3 kg (2.